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Test Code MYPPC Cytogenetics (Fluorescence In-situ Hybridisation) (Expanded MM FISH Panel on targeted plasma cells)

Important Note

Refer to Flow Chart for ordering guide.

All specimens should be shipped to the lab within 12 - 24 hours of collection. Specimen received after 48 hours of collection will nonetheless be processed but results may be compromised. For overseas specimens, avoid shipping on Friday or eve of public holidays.

Additional Codes

EPIC Ordering Code LAB3053044
NBS Code LBA00434, LBC12748
Service Code 1680009,1680010

 

Specimen Requirements

Submit one of the following:

 

Fresh specimen required

 

For (A) and (B):

Preferred: Acceptable:
Green top (Na Heparin) Green top (Li Heparin)

(A) Specimen Type: Bone Marrow 
      Volume: 1.0 - 2.0 mL
      Storage/transport requirement: Ambient

 

(B) Specimen Type: Peripheral Blood
      Volume: 4.0 - 8.0 mL, preferably presence of > 5% blasts
      Storage/transport requirement: Ambient

 

For(C):

Preferred:
Sterile tube with 3.0 mL collection media

(C) Specimen Type: Lymph Node / Solid Tumour / Bone core
      Storage/transport requirements:  Ambient                                                                         (Prearrange with Cytogenetics Laboratory for collection media).

  

For (D):

Preferred:
Sterile Universal Container

(D)  Specimen Type: Effusions (CSF, Pleural Effusion etc)
       Volume: 3.0 - 6.0mL,preferably presence of > 10% cells
       Storage/transport requirement: Ambient

Specimen Stability

Fresh specimen required

Ambient 12 hours (Preferred)
Refrigerate 12 - 48 hours

 

Specimen Condition

Blood 

Haemolysis Alert
Icterus OK
Gross Lipaemia OK
Others (Clotted or Frozen) Reject

Bone Marrow/Effusions

Haemolysis Alert
Icterus OK
Gross Lipaemia OK
Others (Clotted or Frozen) Reject

Lymph Node / Solid Tumour / Bone Core

Haemolysis Not applicable
Icterus Not applicable
Gross Lipaemia Not applicable
Others (Frozen, air-dry or formalin fixed tissue) Reject

 

Methodology

Fluorescence In-situ hybridisation.

Days and Times Performed

Monday through Saturday (Office hours only). TAT 14 days

Reference Interval

An interpretative report will be provided.

Testing Laboratory

National University Hospital
Cytogenetics, 67722512

Useful For

Detection of chromosomal abnormalities in Multiple Myeloma (MM) for t(4;14), t(11;14), t(14;16), deletion and duplication of 1p/1q, deletion of LSI D13S319, monosomy 13 and deletion of LSI TP53.  Refer to Table 2 .

Update

Last updated 14/06//2026

Test Info

This laboratory test has undergone in-house evaluation with appropriate quality assurance and control measures in line with laboratory best practice and accreditation requirements.

Alias

EMYP, PCST

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