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Test Code PMET Metanephrines, fractionated, free, plasma

Specimen Requirements

Specimen Type: Plasma
Container/Tube: Purple (EDTA)

Volume: 3.0 mL whole blood or 1.5 mL plasma
Minimum Volume: 0.6 mL plasma

Collection Instructions: 

Patient should be relaxed in a seated or supine position 30 mins before blood is drawn. Overnight fasting preferred, patient should avoid caffeine/nicotine/alcohol and strenuous exercise 12 hrs prior to blood draw.

 

Centrifuge and separate the plasma within 1 hr of collection. Separated plasma should be stored frozen.

Specimen Stability

Specimen Type  Plasma EDTA
Ambient 6 hours
Refrigerate 10 days
Frozen 14 days (preferred)

Methodology

Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)

Days and Times Performed

Monday and Thursday, TAT 3 - 9 days

Specimen Condition

Haemolysis OK
Icterus OK
Lipaemia OK
Others Not applicable

Reference Interval

Seated Reference Interval:

Normetanephrine, Free: ≤ 1180 pmol/L

Metanephrine, Free: ≤ 510 pmol/L

 

Supine Reference Interval:

Normetanephrine, Free: ≤ 953 pmol/L

Metanephrine, Free: ≤ 371 pmol/L

Testing Laboratory

National University Hospital

Clinical Chemistry, 67728489

Useful For

Screening test for presumptive diagnosis of catecholamine-secreting pheochromocytomas or paragangliomas.

Service Code

33421

Update

Last updated 26/11/2024

Test Classification

This test was developed by NUH Laboratory Medicine. This laboratory test has undergone in-house evaluation with appropriate quality assurance and control measures in line with laboratory best practice and accreditation requirements.

 

Reagents used in this test are ordered through HSA’s Special Access Route, which provides interim access without full registration.