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Test Code P1NP Procollagen Type 1 N-Terminal Propeptide

Additional Codes

Epic Ordering Code LAB3040275
NBS code LBC12836
Service code 36817

Specimen Requirements

Submit only one of the following:

Preferred: Acceptable:
Gold Top Red Top

 

Specimen Stability

Specimen Type Serum
Ambient 24 hours
Refrigerated 5 days
Frozen 6 months

Specimen Condition

Haemolysis Alert/Reject
Icterus Ok
Lipaemia Ok

Methodology

Electrochemiluminescence

Days and Times Performed

Monday through Friday, TAT 1 – 4 days

Reference Interval

Age Male (µg/L)
0 – <1 yr 600 – 3000
1 – <2 yrs 600 – 2000
2 – <3 yrs 300 – 1300
3 – <11 yrs 300 – 950
11 – <16 yrs 300 – 1400
16 – <19 yrs 150 – 850
≥19 yrs 17.4 – 89.9

 

Age Female (µg/L)
0 – <1 yr 600 – 3000
1 – <2 yrs 600 – 2000
2 – <3 yrs 300 – 1300
3 – <9 yrs 300 – 950
9 – <14 yrs 300 – 1200
14 – <15 yrs 150 – 800
15 – <17 yrs 30 – 500
17 – <18 yrs 30 – 300
18 – <23 yrs 30 – 150
23 – <26 yrs 20 – 100
≥26 yrs Premenopause: 17.5 – 80.3
Postmenopause: 19.5 – 105.9

Reference: Chubb S, Vasikaran S, Proposed common reference intervals for reference bone turnover markers in osteoporosis (Pathology, 2026; 58, 181-188)

 

Note: P1NP may be falsely decreased in haemolysed samples

Testing Laboratory

National University Hospital
Clinical Chemistry, 67724346

Useful For

P1NP is a bone formation marker recommended by the International Osteoporosis Foundation (IOF) and International Federation of Clinical Chemistry (IFCC) as the reference marker for assessing bone turnover in osteoporosis. It is also useful in bone health management such as monitoring osteoporosis treatment response and assessing disease activity in Paget's disease of bone and osteoblastic bone metastases.

Update

24/06/2026

LOINC Code Information

47255-5