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LABORATORY COMMUNICATIONS

Laboratory Memos

 

GENERAL INFORMATION

Laboratory Introduction

Laboratory Policies

Professional Staff Organisational Chart

Laboratory Accreditation

Research Support Services

Point of Care Services

Overseas Test Referral Services

Non-NUH Referral Services

 

INFORMATION WEBSITES

National University Hospital 

NUH Referral Laboratory

Mayo Clinic Laboratories

Test Code MGMT MGMT Promoter Methylation test 

Important Note

Please indicate the biopsy number (if available) in EPIC and inform MDC at 67724384.

Laboratory Code

LAB3040009

Specimen Requirements

Preferred
Specimen Type: Tissue Sections
Container/Tube: Slides (uncoated)
Specimen Quantity: One H&E and five unstained sections of 10 micron thickness

Methodology

Methylation-specific Polymerase Chain Reaction

Days and Times Performed

TAT 21 days

Reference Interval

An interpretative report will be provided.

Testing Laboratory

National University Hospital
Molecular Diagnosis Centre, 67724384

Useful For

Epigenetic silencing of the O6-methylguanine-methyltransferase (MGMT) DNA repair gene by promoter methylation has been associated with better response to treatment and improved overall survival in glioma patients receiving alkylating agent in addition to radiotherapy. Methylation-specific polymerase chain reaction provides a qualitative result for the MGMT promoter methylation status.

Service Code

1035073

Update

Last updated 20/03/2025

Test Info

(a)  This test was developed by NUH Laboratory Medicine.

(b) This laboratory test has undergone in-house evaluation with appropriate quality assurance and control measures in line with laboratory best practice and accreditation requirements.