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Test Code MGMT MGMT Promoter Methylation test 

Important Note

Please indicate the biopsy number (if available) in EPIC and inform MDC at 67724384.

Specimen Requirements

Preferred:
Specimen Type: Tissue sections
Container/Tube: Slides (uncoated)
Specimen Quantity: One H&E and five unstained sections of 10 micron thickness

 

Acceptable:
Specimen Type: -
Specimen Quantity: -

Days and Times Performed

Bimonthly, TAT 21 working days.

Methodology

Methylation-specific Polymerase Chain Reaction

Service Code

1035073

Update

Last updated 10/05/2023

Testing Laboratory

National University Hospital
Molecular Diagnosis Centre, 67724384

Useful For

Epigenetic silencing of the O6-methylguanine-methyltransferase (MGMT) DNA repair gene by promoter methylation has been associated with better response to treatment and improved overall survival in glioma patients receiving alkylating agent in addition to radiotherapy. Methylation-specific polymerase chain reaction provides a qualitative result for the MGMT promoter methylation status.

Reference

An interpretative report will be provided.