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Test Code MGMT MGMT Promoter Methylation test 

Important Note

Please indicate the biopsy number (if available) in EPIC and inform GDL at 67724384.

Additional Codes

Epic Ordering Code LAB3040009
NBS code LBC13208
Service code 1035073

Specimen Requirements

Submit the following: 

 

Preferred:
Specimen Type: Tissue Sections
Container/Tube: Slides (uncoated)
Specimen Quantity: One H&E and five unstained sections of 10 micron thickness

Methodology

Methylation-specific Polymerase Chain Reaction

Days and Times Performed

TAT 21 days

Reference Interval

An interpretative report will be provided.

Testing Laboratory

National University Hospital
Genomics Diagnostic Laboratory, 67724384

Useful For

Epigenetic silencing of the O6-methylguanine-methyltransferase (MGMT) DNA repair gene by promoter methylation has been associated with better response to treatment and improved overall survival in glioma patients receiving alkylating agent in addition to radiotherapy. Methylation-specific polymerase chain reaction provides a qualitative result for the MGMT promoter methylation status.

Update

Last updated 11/06/2026

Test Info

(a)  This test was developed by NUH Laboratory Medicine.

(b) This laboratory test has undergone in-house evaluation with appropriate quality assurance and control measures in line with laboratory best practice and accreditation requirements.