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Test Code L3AFP Alpha-Fetoprotein (AFP) L3% and Total, Hepatocellular Carcinoma Tumor Marker, Serum

Additional Codes

Epic Ordering Code LAB3041483
NBS code LBC11755
Service code 36871

Reporting Name

AFP-L3% and Total AFP, S

Specimen Type

Serum


Specimen Required


Collection Container/Tube:

Preferred: Serum Gel

Acceptable: Red Top

Submission Container/Tube: Plastic vial

Specimen Volume: 0.5 mL

Collection Instructions: Centrifuge and aliquot serum into a plastic vial.


National University Hospital-Singapore Note:

NUH Outreach Laboratories:
Specimen Requirements
Submit only one of the following:
Preferred: Gold Top
Acceptable: Red Top
Processing Requirements
Centrifuge and aliquot serum into a plastic vial.
Specimen type: Serum
Volume: 0.5 mL
Storage/transport requirements: Frozen

Forms

If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:

-Oncology Test Request (T729)

-Gastroenterology and Hepatology Test Request (T728)

Specimen Minimum Volume

0.2 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Frozen (preferred) 180 days
  Refrigerated  5 days

Reject Due To

Gross hemolysis Reject
Gross lipemia OK
Gross icterus OK

Method Name

Isotachophoresis with Laser-Induced Fluorescence

Day(s) Performed

Monday through Friday

Report Available

1 to 4 days
National University Hospital-Singapore Note:

Please note that this is a referral test requiring transport to the external testing facility and an additional 3-5 days is required.

Reference Values

Total alpha-fetoprotein (AFP):

<4.7 ng/mL

 

AFP %L3:

<10%

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Useful For

Distinguishing between hepatocellular carcinoma and chronic liver disease

 

Monitoring individuals with hepatic cirrhosis from any etiology for progression to hepatocellular carcinoma

 

Surveillance for development of hepatocellular carcinoma in individuals with a positive family history of hepatic cancer

 

Surveillance for development of hepatocellular carcinoma in individuals within specific ethnic and sex groups who do not have hepatic cirrhosis but have a confirmed diagnosis of chronic infection by hepatitis B acquired early in life, including:

-African men above the age of 20

-Asian men above the age of 40

-Asian women above the age of 50

CPT Code Information

82107

LOINC Code Information

Test ID Test Order Name Order LOINC Value
L3AFP AFP-L3% and Total AFP, S 96451-0

 

Result ID Test Result Name Result LOINC Value
TAFP Total AFP, S 1834-1
L3 %L3 42332-7
INT67 Interpretation 69048-7

Secondary ID

88878

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.
National University Hospital-Singapore Additional Information:

Last updated 10/06/2026