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HelpTest Code IFLCS Free Light Chains, serum
Laboratory Code
LAB735
Specimen Requirements
Specimen Type: Serum
Container/Tube: Gold Top (SSTII) / Red Top
Volume: 5.0 mL / 6.0 mL
Minimum Volume: 0.5 mL serum
Collection Instructions: Allow specimen to clot for 30 mins and centrifuge within 2 hrs.
Specimen Stability
| Specimen Type | Serum |
|---|---|
| Ambient | 8 hours |
| Refrigerate | 21 days (preferred) |
| Frozen | 1 month |
Methodology
Turbidimetry
Days and Times Performed
Monday, Wednesday, Thursday, TAT 2 - 5 days
Specimen Condition
| Mild Haemolysis | OK |
|---|---|
| Gross Icterus | OK |
| Mild Lipaemia | OK |
| Others | Not applicable |
Reference Interval
| Kappa FLC | 3.3 – 19.4 mg/L |
|---|---|
| Lambda FLC | 5.7 – 26.3 mg/L |
| Free Light Kappa to Lambda ratio | 0.26 – 1.65 |
In CKD patients, the free kappa: lambda ratio is: 0.37 - 3.10 (Hutchison et al. Quantitative Assessment of Serum and Urinary Polyclonal Free Light Chains in patients with Chronic Kidney Disease. Clin. J Am Soc Nephril 2008; 3: 1684 - 90).
Testing Laboratory
National University Hospital
Clinical Chemistry, 67724399
Useful For
Elevated serum levels are associated with malignant plasma cell proliferation (e.g. multiple myeloma), lymphocytic neoplasms, Waldenstrom’s macroglobulinemia, amyloidosis and light chain deposition disease and autoimmune disease such as SLE.
Service Code
31605
LOINC Code Information
| Free Light Kappa to Lambda Ratio | 48378-4 |
|---|---|
| Kappa Free Light Chains (FLC) | 36916-5 |
| Lambda Free Light Chains (FLC) | 33944-0 |
Update
Last updated 24/02/2025