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HelpTest Code IFLCS Free Light Chains, Serum
Specimen Requirements
Specimen Type: Serum
Container/Tube: Gold Top (SSTII) / Red Top
Volume: 5.0mL / 6.0mL
Minimum Volume: 0.5mL serum
Collection Instructions: Allow specimen to clot for 30 minutes and centrifuge within 2 hours.
Sample Stability
** Preferred temperatures for storage prior to and during shipping to NUH **
| Specimen Type: | Serum |
|---|---|
| Ambient: | 8 hours |
| Refrigerate: | 21 days |
| Frozen: | 1 month |
Reference Interval
| Kappa FLC | 3.3 – 19.4 mg/L |
|---|---|
| Lambda FLC | 5.7 – 26.3 mg/L |
| Free Light Kappa to Lambda ratio | 0.26 – 1.65 |
In CKD patients, the free kappa: lambda ratio is: 0.37 - 3.10 (Hutchison et al. Quantitative Assessment of Serum and Urinary Polyclonal Free Light Chains in patients with Chronic Kidney Disease. Clin. J Am Soc Nephril 2008; 3: 1684 - 90).
Call back values: NA
Days and Times Performed
Monday, Thursday, TAT 2-5 days
Methodology
Turbidimetry
Service Code
0031605
Update
Last updated 05/09/2024
Updated Sample Stability Frozen
Unacceptable Condition
| Haemolysis | Mild OK |
|---|---|
| Icterus | Mild OK; Gross OK |
| Lipaemic | Mild OK |
| Others | NA |
Testing Laboratory
National University Hospital
Clinical Chemistry, 67724399
Useful For
Elevated serum levels are associated with malignant plasma cell proliferation (e.g. multiple myeloma), lymphocytic neoplasms, Waldenstrom’s macroglobulinemia, amyloidosis and light chain deposition disease and autoimmune disease such as SLE.