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Copeptin proAVP, Plasma

Reporting Name

Copeptin proAVP, P
National University Hospital-Singapore Note:

For NUH patients - use Epic to order (LAB3041447)
NUH service code - 36709
Mayo test code - CPAVP

Useful For

Investigating the differential diagnosis for patients with water balance disorders, including diabetes insipidus, in conjunction with osmolality and hydration status

 

May aid in the evaluation of cardiovascular disease in conjunction with other cardiac markers

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Plasma EDTA


Specimen Required


Patient Preparation: For water-deprivation testing, for at least 8 hours, the patient should fast and thirst (no liquids, including water, are allowed).

Collection Container/Tube: Lavender top (EDTA)

Submission Container/Tube: Plastic screw-top vial

Specimen Volume: 0.5 mL

Collection Information: Centrifuge and aliquot plasma into a plastic vial. Do not submit in original tube.


Specimen Minimum Volume

0.3 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Plasma EDTA Refrigerated (preferred) 7 days
  Frozen  30 days
  Ambient  7 days

Reference Values

Non-water deprived, non-fasting adults*: <13.1 pmol/L

Water deprived, fasting adults**: <15.2 pmol/L

Non-water deprived, non-fasting pediatric patients***: <14.5 pmol/L

Note:

*Keller T, Tzikas S, Zeller T, et al. Copeptin improves early diagnosis of acute myocardial infarction. J Am Coll Cardiol. 2010;55(19):2096-2106. doi:10.1016/j.jacc.2010.01.029

 

**Internal Mayo Clinic study

 

***Du JM, Sang G, Jiang CM, He XJ, Han Y. Relationship between plasma copeptin levels and complications of community-acquired pneumonia in preschool children. Peptides. 2013;45:61-65. doi:10.1016/j.peptides.2013.04.015

Day(s) Performed

Monday through Saturday

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

84588

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CPAVP Copeptin proAVP, P 78987-5

 

Result ID Test Result Name Result LOINC Value
CPAVP Copeptin proAVP, P 78987-5

Reject Due To

Gross hemolysis Reject
Gross lipemia OK
Gross icterus OK

Method Name

Immunofluorescent Assay (IFA)

Secondary ID

603599

Report Available

Same day/1 to 3 days
National University Hospital-Singapore Additional Information:

Updated on 21/03/2022