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Test Code CPAVP Copeptin proAVP, Plasma

Important Note

Sample only has 7 days stability to reach Mayo Laboratories – referring hospital laboratory should contact NUH Laboratory for feasibility.

Additional Codes

Epic Ordering Code LAB3041447
NBS code LBC04158
Service code 36709

Reporting Name

Copeptin proAVP, P

Specimen Type

Plasma EDTA


Specimen Required


Patient Preparation: For water-deprivation testing, for at least 8 hours, the patient should fast and thirst (no liquids, including water, are allowed).

Collection Container/Tube: Lavender top (EDTA)

Submission Container/Tube: Plastic screw-top vial

Specimen Volume: 0.5 mL

Collection Information: Centrifuge and aliquot plasma into a plastic vial. Do not submit in original tube.


National University Hospital-Singapore Note:

NUH Outreach Laboratories:
Specimen Requirements
Submit only one of the following:
Container: Purple Top
Patient Preparation: For water-deprivation testing, for at least 8 hours, the patient should fast and thirst (no liquids, including water, are allowed).
Processing Requirements
Centrifuge and aliquot plasma into a plastic vial. Do not submit in original tube.
Specimen type: Plasma
Volume: 0.5 mL
Storage/transport requirements: Frozen

Specimen Minimum Volume

0.3 mL

Specimen Stability Information

Specimen Type Temperature Time
Plasma EDTA Refrigerated (preferred) 7 days
  Frozen  30 days
  Ambient  7 days

Reject Due To

Gross hemolysis Reject
Gross lipemia OK
Gross icterus OK

Method Name

Immunofluorescent Assay (IFA)

Day(s) Performed

Monday through Saturday

Report Available

Same day/1 to 3 days
National University Hospital-Singapore Note:

Please note that this is a referral test requiring transport to the external testing facility and an additional 3-5 days is required.

Reference Values

Non-water deprived, non-fasting adults*: <13.1 pmol/L

Water deprived, fasting adults**: <15.2 pmol/L

Non-water deprived, non-fasting pediatric patients***: <14.5 pmol/L

Note:

*Keller T, Tzikas S, Zeller T, et al. Copeptin improves early diagnosis of acute myocardial infarction. J Am Coll Cardiol. 2010;55(19):2096-2106. doi:10.1016/j.jacc.2010.01.029

 

**Internal Mayo Clinic study

 

***Du JM, Sang G, Jiang CM, He XJ, Han Y. Relationship between plasma copeptin levels and complications of community-acquired pneumonia in preschool children. Peptides. 2013;45:61-65. doi:10.1016/j.peptides.2013.04.015

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Useful For

Investigating the differential diagnosis for patients with water balance disorders, including diabetes insipidus, in conjunction with osmolality and hydration status

 

May aid in the evaluation of cardiovascular disease in conjunction with other cardiac markers

CPT Code Information

84588

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CPAVP Copeptin proAVP, P 78987-5

 

Result ID Test Result Name Result LOINC Value
CPAVP Copeptin proAVP, P 78987-5

Secondary ID

603599

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.
National University Hospital-Singapore Additional Information:

Last updated 14/07/2026