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HelpTest Code ANCA Anti-Neutrophil Cytoplasmic Antibody (ANCA)
Specimen Requirements
Specimen Type: Serum
Container/Tube: Gold Top (SSTII) / Red Top
Volume: 5.0mL / 6.0mL blood
Minimum Volume: 0.5mL serum
Collection Instructions: Allow specimen to clot for 30 minutes and centrifuge within 2 hours
Sample Stability
** Preferred temperatures for storage prior to and during shipping to NUH **
| Specimen Type: | Serum |
|---|---|
| Ambient: | 2 days |
| Refrigerate: | 2 weeks |
| Frozen: | 1 year |
Reference Interval
MYPO:
No antibody detected: <20 U/mL
Positive: ≥ 20 U/ml
PR3:
No antibody detected: <20 U/mL
Positive: ≥ 20 U/mL
Days and Times Performed
Thursday, TAT 2-8 days
Methodology
Enzyme Immunoassay
Service Code
0032209
Update
last updated 26/02/2022
Unacceptable Condition
| Haemolysis: | NA |
|---|---|
| Icterus: | NA |
| Lipaemic: | NA |
| Others: | NA |
Testing Laboratory
National University Hospital
Clinical Chemistry, 67724346
Useful For
Clinical Usage Autoantibodies against neutrophil cytoplasmic antigens have been found in patients with Wegener’s ranulomatosis, a disease associated with a necrotising granulomatous vasculitis affecting the upper and lower respiratory tract and the kidney. These antibodies have also been observed in microscopic polyarthriitis, SLE and vasculitis. They correlate best in individuals with a necrotising crescentic glomerulonephritis, with or without systemic complications.
Alias
Antineutrophil Cytoplasmic Antibodies (ACPA), Cytoplasmic Neutrophilic Ab, MPO/PR-3 (ANCA)
Antibodies