Home
HelpTest Code ANCA Anti-Neutrophil Cytoplasmic Antibody (ANCA)
Laboratory Code
LAB458
Specimen Requirements
Specimen Type: Serum
Container/Tube: Gold Top (SSTII) / Red Top
Volume: 5.0 mL / 6.0 mL blood
Minimum Volume: 0.5 mL serum
Collection Instructions: Allow specimen to clot for 30 mins and centrifuge within 2 hrs
Specimen Stability
| Specimen Type | Serum |
|---|---|
| Ambient | 2 days |
| Refrigerate | 2 weeks (preferred) |
| Frozen | 1 year |
Panel Information
Panel includes the following tests:
- Anti-Myeloperoxidase IgG
- Anti-Proteinase 3 IgG
Methodology
Enzyme Immunoassay
Days and Times Performed
Thursday, TAT 2 - 8 days
Specimen Condition
| Haemolysis | OK |
|---|---|
| Icterus | OK |
| Lipaemia | OK |
| Others | Not applicable |
Reference Interval
MYPO:
No antibody detected: < 20 U/mL
Positive: ≥ 20 U/ml
PR3:
No antibody detected: < 20 U/mL
Positive: ≥ 20 U/mL
Testing Laboratory
National University Hospital
Clinical Chemistry, 67724346
Useful For
Clinical Usage Autoantibodies against neutrophil cytoplasmic antigens have been found in patients with Wegener’s ranulomatosis, a disease associated with a necrotising granulomatous vasculitis affecting the upper and lower respiratory tract and the kidney. These antibodies have also been observed in microscopic polyarthriitis, SLE and vasculitis. They correlate best in individuals with a necrotising crescentic glomerulonephritis, with or without systemic complications.
Service Code
32209
LOINC Code Information
| MYPO | 48404-8 |
|---|---|
| PR3 | 74106-6 |
Alias
Antineutrophil Cytoplasmic Antibodies (ACPA)
Cytoplasmic Neutrophilic Ab
MPO/PR-3 (ANCA)
Update
Last updated 21/02/2025