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Test Code ALDU Aldosterone, 24 Hour, Urine

Important Note

Collect urine for 24 hrs and record the total urine volume.

Additional Codes

Epic Ordering Code LAB354
NBS code LBC01640
Service code 3186

Reporting Name

Aldosterone, U

Specimen Type

Urine


Ordering Guidance


Advice on stimulation or suppression tests is available from Mayo Clinic's Division of Endocrinology; call 800-533-1710.



Necessary Information


24-Hour volume (in milliliters) is required.



Specimen Required


Patient Preparation: Spironolactone (Aldactone) should be discontinued for 4 to 6 weeks before specimen collection. The plasma renin activity cannot be interpreted if the patient is being treated with spironolactone.

Supplies: Urine tubes, 10 mL (T068)

Container/Tube: Plastic, urine tube

Specimen Volume: 10 mL

Collection Instructions:

1. Add 25 mL of 50% acetic acid as preservative at start of collection. Use 15 mL of 50% acetic acid for children under the age of 5 years. This preservative is intended to achieve a pH of between approximately 2 and 4.

2. Collect urine for a full 24 hours (required) and record the total volume.

Additional Information: See Urine Preservatives-Collection and Transportation for 24-Hour Urine Specimens for multiple collections.


National University Hospital-Singapore Note:

NUH Outreach Laboratories:
Specimen Requirements
Submit the following:
Container: 24 hr urine bottle with Boric Acid as preservative
Processing Requirements
Aliquot urine into a Mayo urine tube
Specimen type: Urine
Volume: 10 mL
Storage/transport requirements: Refrigerated

Urine Preservative Collection Options

Note: Preservative must be added before beginning collection.

Ambient (no additive)

No

Refrigerate (no additive)

No

Frozen (no additive)

No

50% Acetic Acid

Preferred

Boric Acid

OK

Diazolidinyl Urea

No

6M Hydrochloric Acid

No

6M Nitric Acid

No

Sodium Carbonate

No

Toluene

No

Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time
Urine Refrigerated (preferred) 28 days
  Frozen  28 days
  Ambient  14 days

Reject Due To

  All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.

Method Name

Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)

Day(s) Performed

Tuesday, Thursday

Report Available

2 to 8 days
National University Hospital-Singapore Note:

Please note that this is a referral test requiring transport to the external testing facility and an additional 3-5 days is required.

Reference Values

0-30 days: 0.7-11.0 mcg/24 h*

31 days-11 months: 0.7-22.0 mcg/24 h*

≥1 year: 2.0-20.0 mcg/24 h

 

*Loeuille GA, Racadot A, Vasseur P, Vandewalle B. Blood and urinary aldosterone levels in normal neonates, infants and children. Pediatrie. 1981;36(5):335-344

 

For International System of Units (SI) conversion for Reference Values, see www.mayocliniclabs.com/order-tests/si-unit-conversion.html

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Useful For

Investigating primary aldosteronism (eg, adrenal adenoma/carcinoma and adrenal cortical hyperplasia) and secondary aldosteronism (renovascular disease, salt depletion, potassium loading, cardiac failure with ascites, pregnancy, Bartter syndrome) using 24-hour urine collections

CPT Code Information

82088

LOINC Code Information

Test ID Test Order Name Order LOINC Value
ALDU Aldosterone, U 1765-7

 

Result ID Test Result Name Result LOINC Value
8556 Aldosterone, U 1765-7
TM47 Collection Duration (h) 13362-9
VL45 Volume (mL) 3167-4

Secondary ID

8556

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.
National University Hospital-Singapore Additional Information:

Last updated 01/09/2026